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Primary Angiitis of the Central Nervous System: Emerging Variants Q J Med 98:643-654, Maclaren,K.,et al, 2005 See this aricle in Pubmed Article Abstract Direct cerebral angiography was not diagnostic in any case of SVD PACNS; positive brain biopsy is diagnostically unequivocal, but the total clinical syndrome with imaging may establish a diagnosis with highest probability. In MVD PACNS, angiography with MR scan proved diagnostic. We suggest an algorithm for a rational, minimally invasive approach to investigation. In PACNS, SVD and MVD are important variants, and decisions about therapy should incorporate these distinctions.

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